Quick revision ↓ Medical Dictionary
Deep Learning — Module 06
Connect symptoms and examination findings to a differential, targeted investigations, initial priorities and reassessment.
Fever and host context
Document duration, pattern, exposures, travel, contacts, devices, recent procedures and medicines. Fever may arise from infection, inflammation, malignancy or drugs. Immunosuppression, neutropenia and pregnancy alter urgency and the differential. Assess physiological stability first and look for focal symptoms without assuming an absent focus means a minor illness. A patient receiving immunosuppression may have serious infection with muted inflammatory signs.
Specimens and antimicrobial choices
Select cultures and other specimens according to the suspected source, collecting before antimicrobials when feasible without delaying urgent treatment. Contamination can mislead, and a positive culture may represent colonization rather than the cause of illness. Antimicrobial decisions depend on likely pathogens, local resistance, allergy history, organ function and severity. Reassess when results arrive, narrow or stop treatment when appropriate and document indication and review plans.
Tuberculosis and prolonged symptoms
Persistent cough, weight loss, night sweats or compatible extrapulmonary features warrant tuberculosis assessment in context. Microbiological confirmation and resistance testing guide care where available. A negative smear alone does not exclude TB. Use appropriate respiratory precautions and coordinate notification, contact services and programme-based treatment. Do not improvise incomplete regimens, because adherence, toxicity monitoring and resistance prevention require a structured clinical pathway.
Malaria, dengue and enteric illness
Travel or residence, season and local epidemiology guide testing for malaria, dengue and enteric infections. Fever alone cannot reliably distinguish them. Severe illness requires urgent assessment even before confirmation. Thrombocytopenia is not specific to dengue, and a negative test can depend on timing and method. Evaluate hydration, bleeding, organ dysfunction and alternative diagnoses, and use current organism-specific protocols rather than a single empirical treatment for every fever.
HIV, hepatitis and prevention
Offer testing with appropriate consent, confidentiality and counseling, and connect a confirmed diagnosis to care. HIV changes the range of possible infections but does not identify the cause of every symptom. Hepatitis assessment distinguishes current infection, exposure markers, liver injury and chronic disease. Safe injections, vaccination where available and exposure management complement treatment. Explain results without stigma and make plans for follow-up, partner or contact services as appropriate under current guidance.
High-Yield Revision
- The host and exposure history change the fever differential.
- Culture results require source and contamination assessment.
- Review antimicrobial treatment when new evidence arrives.
Common Exam & Concept Pitfalls
- Do not equate every low platelet count with dengue.
- Do not exclude tuberculosis from one negative smear alone.
Sources & Further Reading
Curriculum and reference review: 24 September 2026. These original notes teach clinical reasoning and recognition, not standalone prescribing or procedure protocols. International guidance supports the principles below; local pathways, resources and authorized supervision govern patient care. Faculty review is pending.
- PM&DC MBBS Curriculum 2024 — Medicine & Allied overview (printed page 20) and General Medicine section (from page 74)
- Acute assessment: Resuscitation Council UK: ABCDE · NICE adult sepsis recognition · Anaphylaxis guidance
- Cardiology: NICE acute coronary syndromes · Heart failure · Atrial fibrillation
- Respiratory: GINA 2026 asthma summary guide
- Gastrointestinal and renal care: NICE upper gastrointestinal bleeding · Acute kidney injury
- Endocrinology: 2024 multi-society hyperglycemic crises consensus · NICE thyroid disease
- Neurology: NICE stroke and TIA · Bacterial meningitis
- Allied care: NICE neutropenic sepsis · Rheumatoid arthritis · Self-harm assessment
- Continuity and safety: NICE delirium · Multimorbidity · WHO Medication Without Harm · WHO patient safety solutions
