Quick revision ↓ Medical Dictionary
Deep Learning — Module 02
Connect symptoms and examination findings to a differential, targeted investigations, initial priorities and reassessment.
Structured first response
Use an airway, breathing, circulation, disability and exposure approach to identify immediate threats, call for help and reassess after interventions. Assess responsiveness and breathing immediately; an unresponsive person who is not breathing normally needs the applicable resuscitation response. Obtain observations and monitoring without delaying essential care. The sequence organizes priorities but is not a reason to ignore major bleeding or other obvious life-threatening problems while waiting to complete a checklist.
Shock and perfusion
Shock means inadequate tissue perfusion and may be hypovolemic, distributive, cardiogenic or obstructive, sometimes with mixed mechanisms. Altered mentation, cool or mottled skin, reduced urine output and rising lactate can support concern; blood pressure alone does not describe the entire circulation. Look for bleeding, infection, cardiac dysfunction or obstruction. Treatment depends on cause and response, and repeated reassessment is essential because indiscriminate fluid can worsen some conditions.
Sepsis recognition
Sepsis is life-threatening organ dysfunction caused by a dysregulated response to infection. Fever is neither required nor sufficient. Consider new confusion, respiratory compromise, hypotension or reduced urine output with possible infection, especially in vulnerable patients. Early warning scores support recognition but do not replace clinical judgment. Obtain relevant cultures and tests when feasible without delaying time-critical treatment, and arrange prompt senior review, antimicrobials and source control according to local protocols.
Oxygen, fluids and monitoring
Assess oxygenation and ventilation separately; a pulse oximeter does not measure carbon dioxide. Oxygen is prescribed to an appropriate target with reassessment, including consideration of hypercapnic respiratory failure. Fluid decisions need volume status, cardiac and renal context, type of loss and response. Monitor mental state, circulation, respiratory effort and urine output. Escalating oxygen requirement or worsening consciousness can be more important than an apparently acceptable single number.
Reassessment and escalation
Record treatment, timings and response, communicate deterioration clearly and request a level of care capable of the needed support. Hypoglycemia, arrhythmia, anaphylaxis and other causes can mimic or coexist with infection. Do not let a sepsis label prevent examination for bleeding or obstruction. After immediate stabilization, investigate the precipitant and complications and hand over ongoing monitoring needs and explicit escalation criteria.
High-Yield Revision
- Shock can be present before profound hypotension.
- Treat threats and reassess while seeking the cause.
- A score supports but does not replace judgment.
Common Exam & Concept Pitfalls
- Do not exclude sepsis because fever is absent.
- Do not give repeated fluid without checking response and overload risk.
Sources & Further Reading
Curriculum and reference review: 24 September 2026. These original notes teach clinical reasoning and recognition, not standalone prescribing or procedure protocols. International guidance supports the principles below; local pathways, resources and authorized supervision govern patient care. Faculty review is pending.
- PM&DC MBBS Curriculum 2024 — Medicine & Allied overview (printed page 20) and General Medicine section (from page 74)
- Acute assessment: Resuscitation Council UK: ABCDE · NICE adult sepsis recognition · Anaphylaxis guidance
- Cardiology: NICE acute coronary syndromes · Heart failure · Atrial fibrillation
- Respiratory: GINA 2026 asthma summary guide
- Gastrointestinal and renal care: NICE upper gastrointestinal bleeding · Acute kidney injury
- Endocrinology: 2024 multi-society hyperglycemic crises consensus · NICE thyroid disease
- Neurology: NICE stroke and TIA · Bacterial meningitis
- Allied care: NICE neutropenic sepsis · Rheumatoid arthritis · Self-harm assessment
- Continuity and safety: NICE delirium · Multimorbidity · WHO Medication Without Harm · WHO patient safety solutions
