Pharmacology Practice

20 learning units • 10 questions per unit • 200 explained questions

Module 02 — Pharmacokinetics & Dose Calculations

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Question 01 • Single best answer

Which quantity describes the fraction of an oral dose reaching systemic blood unchanged?

A. Bioavailability B. Clearance C. Intrinsic efficacy D. Therapeutic index

Question 02 • Single best answer

What is the apparent volume of distribution for 400 mg in the body at a plasma concentration of 10 mg/L?

A. 4 L B. 4000 L C. 40 L D. 0.025 L

Question 03 • Single best answer

Which change usually increases free fraction for a highly albumin-bound drug?

A. Increased tablet size B. Lower receptor affinity C. Reduced gastric acidity alone D. Reduced albumin concentration

Question 04 • Single best answer

Which statement about metabolism is correct?

A. Metabolism always inactivates every drug B. A metabolite may be active or toxic C. Phase II always requires prior phase I D. Only kidneys metabolize medicines

Question 05 • Single best answer

With linear kinetics, approximately when is steady state approached?

A. After one minute for every drug B. Only after the final dose C. After four to five half-lives D. Immediately after any oral dose

Question 06 • Single best answer

Which parameter chiefly determines maintenance dose rate at a fixed target concentration?

A. Tablet color B. Receptor number alone C. Drug brand D. Clearance

Question 07 • Single best answer

What is a simplified IV loading dose for a target of 10 mg/L and Vd of 40 L?

A. 4 mg B. 400 mg C. 40 mg D. 4000 mg

Question 08 • Single best answer

What IV maintenance rate maintains 10 mg/L when clearance is 4 L/hour in a linear model?

A. 2.5 mg/hour B. 40 mg/hour C. 400 mg/hour D. 0.4 mg/hour

Question 09 • Single best answer

What characterizes first-order elimination?

A. A constant fraction is eliminated per unit time B. A fixed number of milligrams is always removed regardless of concentration C. No drug is metabolized D. Half-life is always one hour

Question 10 • Single best answer

Why can a small dose increase cause a large concentration rise for a saturably eliminated drug?

A. Elimination capacity becomes limited B. Bioavailability must become zero C. Receptors disappear immediately D. All drugs follow identical linear kinetics