Pharmacology Assessment

20 learning units • 10 questions per unit • 200 explained questions

Module 03 — Pharmacodynamics & Receptor Signalling

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Question 01 • Single best answer

Two drugs have the same Emax but different EC50 values. Which differs?

A. Potency B. Maximum efficacy C. Route necessarily D. Chemical purity necessarily

Question 02 • Single best answer

What does a reversible competitive antagonist typically do to an agonist curve?

A. Always doubles the maximum B. Eliminates every receptor permanently C. Shifts it rightward with a preserved maximum D. Shifts it leftward by increasing potency

Question 03 • Single best answer

A partial agonist is added to a full agonist at the same receptor. What can happen?

A. Maximal response must double B. Overall response can decrease C. Binding becomes impossible for both D. All adverse effects disappear

Question 04 • Single best answer

Which receptor type directly regulates gene transcription after ligand binding?

A. Ligand-gated sodium channel B. Nuclear receptor C. Cell-surface adhesion molecule only D. Voltage-gated calcium channel

Question 05 • Single best answer

Which action need not involve a receptor?

A. Beta-2 agonist bronchodilation B. Muscarinic blockade by atropine C. Neutralization of gastric acid by an antacid D. Insulin receptor activation

Question 06 • Single best answer

What does a quantal dose-response curve measure?

A. Proportion of people reaching a defined endpoint B. Magnitude of contraction in one tissue only C. Tablet dissolution time only D. Number of drug brands

Question 07 • Single best answer

What is tachyphylaxis?

A. Increased renal filtration in every patient B. Permanent receptor activation C. First-pass metabolism D. Rapid decline in response with repeated exposure

Question 08 • Single best answer

Which ratio commonly expresses therapeutic index?

A. ED50 divided by tablet weight B. EC50 multiplied by clearance C. TD50 divided by ED50 D. Bioavailability divided by age

Question 09 • Single best answer

Why does increasing a drug dose sometimes cause new off-target effects?

A. Every receptor becomes more selective B. Selectivity may diminish at higher concentrations C. The molecule changes its generic name D. Absorption must stop completely

Question 10 • Single best answer

Two sedating medicines worsen respiratory depression without changing concentrations. What interaction is this?

A. Pharmaceutical incompatibility in an IV bag B. Pharmacodynamic C. Reduced oral bioavailability D. Increased renal clearance

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